I've been thinking for a while about a campaign framework for a World of Darkness game for a group of players who know virtually nothing about the setting. That lack of knowledge makes running a Vampire or Werewolf game very hard, but straight-up Hunter doesn't exactly fit what I want either. I've come up with several different ones, but recently I came up with one that I think has legs.
The setting of the campaign is Chicago, mostly in the neighborhood of Rogers Park (where I lived for 7 years). Since I love the city, and think it's a great WoD setting, this makes sense. The PCs are newly assigned members of a gang crime task force that includes the Chicago police, the prosecutor's office, and several federal agencies. In particular, the players are assigned to the section of the task force dealing with Russian gangs in the Rogers Park area.
However, all is not as it seems--the PCs are acting as undercover agents because the Feds suspect corruption. Someone on the task force--maybe several people--has been bought by the gangs, and is sabotaging the task force. So the PCs' real job is to find out who the corrupt people are, and take them down.
How is this a World of Darkness game? Lurking in the background are supernatural forces. The PCs don't know about this, and neither do the players, which makes it good for WoD newcomers. It also presents all kinds of opportunities for intrigue and deception, which is what a good WoD game should have (at least I think so).